Kode - Chemoinformatics
with the retinoid X receptor (RXR) to vitamin D response Supplementary key words nuclear receptor • structure-function rela- .. function relationships in the vitamin D endocrine system. . Crystallography & NMR system: a new software. 5NKY: Structure-activity relationship study of vitamin D analogs with oxolane group in their 5NKY_A_AC1_12 binding site for residue 91W A (Software) . PASS (Prediction of Activity Spectra for Substances) software product. PASS predicts SAR/QSAR/QSPR/Molecular Modelling methods are .. Vitamin D-like .
To date, research on the association between BMD with these parameters has primarily focused on postmenopausal women 18 However, research focusing on the young adult population is extremely important as peak bone mass is achieved during this phase of life years-old The present cross-sectional study was carried out among Malay students 50 males and 50 females at Universiti Kebangsaan Malaysia UKM.
Subjects were between years old, selected based on convenient sampling and recruited through advertisements posters and flyers and referrals. Subjects were included if they were healthy and non-smokers. Subjects were excluded if they had taken calcium or vitamin D supplements or any medications known to affect bone metabolism, were pregnant or lactating mothers and those diagnosed with a disease related to bone health.
The body weight and height without shoes of subjects were recorded using a combined digital weight and height scales SECAHamburg, Germany to the nearest 0. The BMI was calculated by dividing body weight kg by the square of body height m2.
Assessment of calcium intake: Calcium intake was assessed using a validated semi-quantitative food frequency questionnaire FFQ The FFQ consisted of 80 food items categorized into 11 groups. The subjects were asked about the frequency with which they ingested each food item per day, week, or month and the serving size. The FFQ was administered by a trained researcher through one-on-one interviews. Various sizes of food portions were referenced based on a food photo album, which was used as a guide during the interview The frequency of intake was based on habitual intake in the previous month.
Formula of the conversion of food frequency to the amount of intake was calculated as follow Assessment of serum Hydroxyvitamin D: Only 94 blood samples were taken from consenting subjects for this assessment. The serum 25 OH D concentration was determined by the electro chemiluminescence protein binding assay method on a Cobas e analyzer Roche Diagnostics, Mannheim, Germany.
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Then, blood samples were outsourced to the University Malaya Medical Centre for biochemical analyses. Using the manufacturers standard guidelines, quality control and calibration were conducted before each data collection session began. According to current WHO recommendations, the ultrasound-derived T-scores were automatically calculated by the built-in software and classified according to the WHO criteria1. T-scores above -1 were defined as a normal BMD, T-scores between -1 and Each T-score was compared with a healthy young adult reference population.
Data were analyzed using Statistical Package for Social Science version Prior to the analyses, the data were checked for normal distribution using the Kolmogorov-Smirnov test. All parameters were normally distributed, hence, the parametric test was used.
IMMUNE THROMBOCYTOPENIA AND VITAMIN D DEFICIENCY. EHA Learning Center. Tham C. Jun 14 ;
The Pearson correlation was used to investigate the relationship between bone-related variables and BMD. Statistical significance was defined as a p-value of 0.
Table 1 shows the general characteristics of studied subjects. The mean age of subjects was Weight and height of male subjects Table 2 shows that the average calcium intake of subjects Body mass index Table 2: Malaysian recommended nutrient intake Table 3: Broadband ultrasound attenuation, bUltrasound-derived T-score, compared with a younger reference population, cBMD: While male subjects had a higher mean calcium intake While the overall T-score of all subjects was associated with a normal BMD 1.
None of the subjects were classified with osteoporosis. Correlation of bone-related variables with BMD: Table 5 shows the correlation between bone-related variables and BMD.
Broadband ultrasound attenuation, b25 OH D: These results are consistent with those of Montazerifar et al. This can largely be explained by a higher BMI contributing to an increase mechanical load on bones leading to remodelling This pathophysiological mechanism may also apply to patients with ITP, in which case, correcting vitamin D deficiency would be a safe way of aiding treatment.
Aims Assess whether there is a relationship between ITP and vitamin D deficiency in both adults and children. Methods Adult and pediatric ITP patient cohorts were retrospectively analysed, comprising of and 34 patients respectively.
The pediatric cohort was further divided into acute 11 and chronic 23 groups. Those with repeat vitamin D tests were categorised as — increased, unchanged or decreased vitamin D level, based on category replete, insufficient or deficient rather than numerical value. Results In the pediatric chronic ITP group, of the 20 patients tested, the mean vitamin D level was In the acute ITP group 6 patients were tested, the mean vitamin D level was In the adult cohort of patients, mean age 45 years had vitamin D levels and platelet counts tested.
Structure-activity relationship study of vitamin D analogs with oxolane group in their side chain.
The mean level was When stratified by severity of thrombocytopenia, there was no significant difference between groups. There were significantly more patients deficient in winter and spring compared to in summer and autumn.
Plotting numerical values of vitamin D level against platelet count showed little correlation, with a Pearson R value of